Jason Calacanis annoys me in so many ways, but at the same time there's something fascinating about him. Regarding stress and entrepreneurs, he had this to say:
In some ways I think I've realized that life is just a big video game and if one game doesn't work out you put another quarter in and try again. It's no big deal. That's the great part of the society and time we live in: you can go for it, fail, and then go for it again. Nothing is lost, a lot of experience is gained. You can't act a fool, but you can reach for the stars and miss.
I know certain people who should print that out and frame it, applying the concept to career, relationships and everything in life.